Research

sartor

Oliver Sartor, MD

Dr. Sartor has been involved in a leadership role with a Phase III trial prolonging survival in advanced prostate cancer. The first trial, subsequently published in Lancet, involved second-line chemotherapy with Cabazitaxel, which gained FDA approval in June 2010. This was the first trial to demonstrate a survival benefit after initial chemotherapy had failed. Dr. Sartor was the international co-principal investigator for this trial and senior author on the Lancet paper.

In the new trial, recently announced, the use of the new isotope Radium 223 has resulted in a prolong survival of a polaroid of patients with advanced metastatic prostate cancer, and this is the first radio-pharmaceutical to prolong life in prostate cancer. Dr. Sartor was the North American principal-investigator in this trial. Dr. Sartor was a local investigator (but without a national leadership role) in a third trial using Abiraterone, which led to a prolongation in survival in metastatic prostate cancer. He is currently involved with his fourth Abiraterone study, which is the first second-line hormonal agent to demonstrate survival benefits. Abiraterone is now FDA approved.

He currently runs approximately ten clinical trials in prostate cancer, and he is a national co-principal investigator in three of these trials.

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Asim Abdel-Mageed, PhD
Active Research Projects

“Targeting Tumor-Derived exRNA-Containing Microvesicles by High Throughput Screening”
“Estrogen-ER Axis in Disparity of Prostate Cancer”
“Adipose stem cell-based therapeutic targeting of residual androgens in African Americans with bone metastatic prostate cancer”

Dr. Abdel-Mageed’s laboratory primarily focuses on basic research into the cellular and molecular aspects of urologic diseases, with particular attention given to prostate and bladder cancer. The laboratory has a special interest in identifying molecular determinants of prostate cancer progression, using in-vitro and in-vivo experimental approaches.

Sikka

Suresh Sikka, PhD

Men’s Health (Male Infertility, Sexual Dysfunction, Genitourinary Inflammation, Prostate Diseases, Environmental Reproductive Toxicology, Role of Oxidative Stress/Antioxidants, Sperm Safety Multicenter Clinical Studies, Forensic Applications, Endocrine Disruptors, and Andropause)

Male Infertility:

  • Diagnosis
  • Treatment
  • Assisted Reproduction Technology (ART)
  • Oxidative Stress and Role of Antioxidants
  • Testicular Toxicology
  • Standardized S/E Training Program
  • DNA Identification
  • Chromosome Evaluation

Sexual Health:

  • Erectile Dysfunction (ED)
  • Peyronie’s Disease
  • Oxidative Stress and Role of Antioxidants
  • Role of Stem Cells

Prostate Health:

  • BPH
  • Prostatitis and GUI
  • Lower Urinary Tract Symptoms (LUTS)
  • Male Aging (Andropause)
  • Hypogonadism & Hormone Replacement
  • Prostate Cancer